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用小鼠移植性肿瘤和裸鼠异体移植人肿瘤模型研究骆驼蓬总碱(TAH)抗肿瘤作用及其协同抗瘤作用。结果表明:TAH对小鼠S-180、LⅡ、肝癌以及裸鼠移植人鼻咽癌(CNE2)和人(BEL-7402)肝癌均有抗肿瘤作用,并发现TAH与顺铂(DDP)或阿霉素(ADM)合用,具有协同抗肿瘤作用。
The anti-tumor effect of total alkaloids (TAH) from Peganum harmonii and its synergistic anti-tumor effect were studied using mouse transplantable tumor and human allograft tumor model in nude mice. The results showed that TAH had anti-tumor effects on mouse S-180, LII, liver cancer and nude mice transplanted with human nasopharyngeal carcinoma (CNE2) and human (BEL-7402) liver cancer, and found that TAH and cisplatin (DDP) or Ah The combination of ADM (ADM) has a synergistic anti-tumor effect.