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目的:探讨地佐辛联合芬太尼对肺癌术后患者镇痛效果的影响及预后情况的相关机制。方法:分析我院胸外科2013年5月~2014年9月收治的78例行肺癌根治术术后患者的临床资料,按照镇痛方法的不同分为对照组和观察组,对照组(41例)给予芬太尼1ug/kg镇痛,观察组(37例)给予地佐辛0.5mg/kg与芬太尼1μg/kg联合镇痛。比较两组患者呼吸功能指标、VAS评分及不良反应的发生情况。结果:通过呼吸功能指标(MVV、FEV_1、FVC)、VAS评分及不良反应发生率的分析,观察组患者与对照组患者对比差异均具有统计学意义;观察组术后患者经Kaplan-Meier生存曲线分析可知,患者2年累积生存率与VAS评分的高低相关,数值差异有统计学意义。结论:地佐辛联合芬太尼使用后可明显改善肺癌术后患者的镇痛效果,且减少了不良反应的发生,安全性高,VAS评分可作为肺癌术后患者预后情况的评价指标。
Objective: To investigate the effect of dezocine combined with fentanyl on the analgesic effect of postoperative patients with lung cancer and the related mechanism of prognosis. Methods: The clinical data of 78 patients who underwent radical surgery for lung cancer who were admitted to our hospital from May 2013 to September 2014 were analyzed retrospectively. The patients were divided into control group, observation group and control group (41 cases ) Were given fentanyl 1ug / kg analgesia. The observation group (37 cases) was given dezocine 0.5mg / kg and fentanyl 1μg / kg analgesia. The respiratory function indexes, VAS score and adverse reactions of the two groups were compared. Results: Through the analysis of respiratory function index (MVV, FEV_1, FVC), VAS score and incidence of adverse reactions, the difference between the observation group and the control group was statistically significant; the postoperative Kaplan-Meier survival curve Analysis shows that the 2-year cumulative survival rate of patients with VAS score was related to the level of the difference was statistically significant. Conclusion: Dezocine combined with fentanyl can significantly improve the analgesic effect of postoperative lung cancer patients, and reduce the incidence of adverse reactions, high safety, VAS score can be used as a prognostic indicator of postoperative lung cancer patients.