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目的:探讨中药制剂“阻育丸”对雌性SD大鼠毒副作用。方法:根据祖传秘方(单方)制成中药制剂“阻育丸”。选择4月龄雌性SD大鼠,根据阴道涂片结果,选择动情前期1次顿服“阻育丸”3.75 g/kg,并进行服药前与服药后肝功能、肾功能、血K+、Na+、Cl-的比较及行解剖学检查。结果:服用“阻育丸”后肝功能、肾功能、血K+、Na+、Cl-未见显著性变化。病理切片卵巢组织中仅见各级发育的卵泡,未见排卵及黄体形成。结论:“阻育丸”用于绝育是一种简单方便、安全高效、价廉无痛苦的绝育方法。
Objective: To investigate the toxic and side effects of traditional Chinese medicine preparation “bearing pill” on female SD rats. Method: According to the ancestral secret recipe (unilateral) made of traditional Chinese medicine preparation “resistance pill”. Select 4-month-old female SD rats, according to the results of vaginal smears, select the first time estrus Dayton “resistance pills ” 3.75 g/kg, and before and after taking medication liver function, renal function, blood K +, Comparison of Na+, Cl- and anatomical examination. Results: There was no significant change in liver function, renal function, blood K+, Na+, and Cl- after taking the “resistance pill.” Only ovarian follicles at all levels were found in pathological sections of the ovarian tissue, and no ovulation or corpus luteum formation was observed. Conclusion: The “resistance pills” for sterilization is a simple, convenient, safe and efficient, inexpensive and painless method of sterilization.