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目的观察服用小剂量倍他乐克对部队战士应急训练 (5km越野 )过程中心率变异的影响 ,评价小剂量倍他乐克对运动过程中心血管自主神经的调节作用。方法 80名 18～ 2 2岁男性战士 ,随机分为倍他乐克组 (倍他乐克 6 .2 5mg·次 1,每日 2次 ,共 1周 )和对照组 (安慰剂 )。测量受试者运动前后血糖、血乳酸及血浆儿茶酚胺 (E、NE)的浓度 ;采用Holter记录运动前 10min ,运动中 30min及运动后 2 0min的心电信号 ,进行心率变异 (HRV)分析。结果应急训练可显著升高血糖、血乳酸 ,但服用倍他乐克和安慰剂后 ,两组均无显著差异 ;运动使血浆E和NE显著升高(P <0 .0 1) ,对照组NE较倍他乐克组升高更显著 (P <0 .0 5 )。两组在运动中低频峰 (LF)均升高 ,高频峰 (HF)下降 ,LF/HF升高。对照组LF较倍他乐克组升高更为显著〔(191.4± 30 .8)(b·min 1) 2 /Hz vs .(16 9.8± 32 .7) (b·min 1) 2 /Hz ,P <0 .0 5〕 ,而HF下降更显著〔(34.4± 11.4 )(b·min 1) 2 /Hzvs .(5 7.2± 12 .4 ) (b·min 1) 2 /Hz ,P <0 .0 5〕。结论应急训练使心脏交感神经兴奋 ,迷走神经抑制 ,心率变异性降低 ;小剂量倍他乐克可提高应急训练时的心率变异性 ,使心脏交感神经和迷走神经的平衡调节改善
Objective To observe the effect of low-dose Betaloc on the rate-of-heart rate variability during troop warrior emergency training (5km off-road) and to evaluate the regulatory effect of low-dose Betaloc on cardiovascular autonomic nervous system during exercise. Methods Eighty male warriors aged 18-2 2 years were randomly assigned to metoprolol (metoprolol 6.52 mg twice daily for 1 week) and control group (placebo). The blood glucose, blood lactate and plasma catecholamine (E, NE) concentrations were measured before and after exercise. Heart rate variability (HRV) analysis was performed using Holter to record the electrocardiographic signals 10 minutes before exercise, 30 minutes after exercise and 20 minutes after exercise. Results Emergency training significantly increased blood glucose and blood lactate, but there was no significant difference between the two groups after taking betametazole and placebo. Exercise induced a significant increase in plasma E and NE (P <0.01), while in the control group NE was more significant than betaxolol (P <0.05). Both groups had higher LF, LF, HF and HF in exercise. The level of LF in the control group was significantly higher than that in the metoprolol group (191.4 ± 30.8) (b · min 1) 2 / Hz vs. (16 9.8 ± 32.7) (b · min 1) 2 / Hz , P <0.05), while HF decreased more significantly (34.4 ± 11.4) (b · min 1) 2 / Hz vs (5.2 ± 12.4) (b · min 1) 2 / Hz, P < 0 .0 5〕. Conclusions Emergency training can make the heart sympathetic nerve excited, the vagus nerve inhibition and the heart rate variability reduce. The low dose Betaloc can improve the heart rate variability in emergency training and improve the balance of the sympathetic and vagal balance in the heart