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采用固相放射免疫分析法在２４例胃癌和１２例结直肠癌患者的肿瘤组织抽提液中测定糖链抗原ＣＡ１９－９含量。结果显示癌组织中ＣＡ１９－９的平均水平显著高于正常组织（Ｐ＜０．０１）；３６例肿瘤患者有３１例（８６％）癌组织中的ＣＡ１９－９含量明显高于对应的正常组织；瘤体较大的癌组织中ＣＡ１９－９水平与瘤体小的相比差别具有统计学意义（Ｐ＜０．０１）；ＣＡ１９－９水平与淋巴结转移状况和组织学类型无相关性，提示胃肠肿瘤细胞合成ＣＡ１９－９增加，该指标对判断胃肠恶性组织可能具有一定的价值。
The solid-phase radioimmunoassay was used to determine the content of carbohydrate antigen CA19-9 in tumor tissue extracts from 24 patients with gastric cancer and 12 patients with colorectal cancer. The results showed that the average level of CA19-9 in cancer tissues was significantly higher than that in normal tissues (P<0.01); the content of CA19-9 in cancer tissue was significantly higher in 31 tumor tissues (86%) than the corresponding normal tissues. There was a statistically significant difference in the level of CA19-9 in tumors with larger tumors and small tumors (P<0.01); there was no correlation between CA19-9 levels and lymph node metastasis and histological types. Gastrointestinal tumor cells increase the synthesis of CA19-9, which may be of value in judging the malignant tissue of the stomach and intestines.