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干扰素(IFN)是有核细胞对病毒或双股 RNA 刺激人体产生的免疫应答中所合成和分泌的宿主衍生蛋白,它具有抗病毒、抑制细胞增殖和免疫调节等特性。天然干扰素(IFNs)由16种不同蛋白或糖蛋白组成,依其来源和抗原性分为α、β和γ三种,分别由人白细胞、纤维母细胞和淋巴母细胞产生。80年代初重组技术成功后,将人 IFN 基因转化到大肠杆菌或酵母菌可大量生产各型重组干扰素(γIFNs),为广泛临床应用创造了有利条件.慢性乙型肝炎(CHB)病人和慢性 HBV携带者(肝活检证实大多有不同程度肝病)IFNs 产生低下,对外源性 IFN 起反应。1976年 Greenberg 首次用人白细胞干扰素(Hu—
Interferon (IFN) is a host-derived protein that is synthesized and secreted by nucleated cells in response to a virus or double-stranded RNA that stimulates the human body to produce antiviral, cytostatic and immunomodulatory properties. Natural interferons (IFNs) are composed of 16 different proteins or glycoproteins and are classified into α, β and γ according to their origin and antigenicity. They are produced by human leukocytes, fibroblasts and lymphoblasts respectively. After recombinant technology was successful in the early 1980s, the human IFN gene was transformed into Escherichia coli or yeast to produce large quantities of various types of recombinant IFNs (γIFNs), which has created favorable conditions for a wide range of clinical applications. Chronic hepatitis B (CHB) patients and chronic HBV carriers (liver biopsy confirmed that most have varying degrees of liver disease) IFNs are low, the response to exogenous IFN. 1976 Greenberg first human leukocyte interferon (Hu-