Background The diagnosis of small bowel diseases remains relatively inefficient using traditional imaging techniques.Capsule endoscopy(CE)and double-balloon enteroscopy(DBE)are two novel methods of enteroscopy for examiningthe entire small bowel.The aim of this study was to evaluate the detection rate and diagnostic accuracy of CE and DBEin patients with suspected small bowel diseases and to investigate the clinical significance of combined use of these twonovel modalities.Methods Two hundred and eighteen patients were evaluated for suspected small bowel disease,including 116 withobscure gastrointestinal bleeding and 102 with obscure abdominal pain or chronic diarrhea.One hundred and sixty-fiveout of these patients underwent CE first and 53 patients underwent DBE(under anesthesia with propofol)first.DBE wasrecommended after negative or equivocal evaluation on CE and vise versa.Introduction of the endoscope during DBEwas either orally or anally and the patients were referred for a second procedure using the opposite route several dayslater when no abnormalities were found on the first procedure.The detection rates,diagnostic accuracy,tolerance andfrequency of adverse events of these two modalities were then analyzed.Results Failure of the procedure was seen in one patient with CE and in two patients with DBE.Sixty-four DBEprocedures were carried out in 51 patients;by the oral route in 34 cases,the anal route in 4 and both routes in 13 cases.The overall detection rate of small bowel diseases using CE(72.0%,118/164)was superior to that with DBE(41.2%,21/51);x~2=16.1218,P<0.0001.The diagnostic rate(51.8%,85/164)was also higher than that with the latter procedure(39.2%,20/51),but was not significantly different(x~2=2.4771,P>0.05).Furthermore,the detection rate of small boweldiseases in patients with obscure gastrointestinal bleeding using CE(88.0%,88/100)was superior to that of DBE(60.0%,9/15);x~2=7.7457,P=0.0054.Lesions were detected by DBE in 1 out of 4 patients in whom CE had a negative result.Suspected findings by CE were confirmed by DBE combined with biopsy in 12 out of 15 patients.On the other hand,small bowel lesions were identified by CE in all 3 patients after negative evaluations by DBE.There were no severecomplications during or after either of the two procedures.Conclusions The detection rate of small bowel diseases by CE is very high.CE should be selected for the initialdiagnosis in patients with suspected small bowel diseases,especially in patients with obscure gastrointestinal bleeding.DBE appears to be inferior to CE in the diagnosis of small bowel diseases.However,it was shown that abnormalitiescould still be identified by DBE in patients with normal images or used to confirm suspected findings from CE.DBE canalso serve as a good complementary approach after an initial diagnostic imaging using CE. Background The diagnosis of small bowel diseases remains relatively inefficient using traditional imaging techniques. Capsule endoscopy (CE) and double-balloon enteroscopy (DBE) are two novel methods of enteroscopy for examining the entire small bowel.The aim of this study was to evaluate the detection rate and diagnostic accuracy of CE and DBEin patients with suspected small bowel diseases and to investigate the clinical significance of combined use of these twonovel modalities. Methods Two hundred and eighteen patients were evaluated for suspected small bowel disease, including 116 with obscure gastrointestinal bleeding and 102 with Obscure abdominal pain or chronic diarrhea. One hundred and sixty-five out of these patients underwent CE first and 53 patients underwent DBE (under anesthesia with propofol) first. DBE wasrecommended after negative or equivocal evaluation on CE and vise versa. Introduction of the endoscope during DBEwas either orally or anally and the patients were referred for a secon d procedure using the opposite route several dayslater when no abnormalities were found on the first procedure. detection rates, diagnostic accuracy, tolerance and frequency of adverse events of these two modals were then analyzed. Results Failure of the procedure was seen in one patient with CE and in two patients with DBE. Sixty-four DBE procedures were carried out in 51 patients; by the oral route in 34 cases, the anal route in 4 and both routes in 13 cases. The overall detection rate of small bowel diseases using CE (72.0 Was superior to that with DBE (41.2%, 21/51); x ~ 2 = 16.1218, P <0.0001. The diagnostic rate (51.8%, 85/164) was also higher than that with the latter The detection rate of small boweldiseases in patients with obscure gastrointestinal bleeding using CE (88.0%, 88/100) was significantly higher than that of the control (39.2%, 20/51), but was not significantly different (x ~ 2 = 2.4771, ) was superior to that of DBE (60.0%, 9/15); x ~ 2 = 7.7457, P = 0.0054. Lesions were detected by DBE in 1 out of 4 patients in whom CE had a negative result. Commonly anticipated by CE was confirmed by DBE. Combined with biopsy in 12 out of 15 patients. On the other hand, small bowel lesions were identified by CE in all 3 patients after negative evaluations by DBE.There were no Sevecomplications during or after either of the two procedures. Conclusions The detection rate of small bowel diseases by CE is very high. CE should be selected for the initial diagnosis of in-patients with suspected small bowel diseases, especially in patients with obscure gastrointestinal bleeding. DBE appears to be inferior to CE in the diagnosis of small bowel diseases.However, it was shown that abnormalities could still be identified by DBE in patients with normal images or used to confirm suspicions of findings from CE.DBE canalso serve as a good complementary approach after an initial diagnostic imaging using CE.