论文部分内容阅读
Objective.To identify the A3243G mutation of mi tochondrial(mt )DNA in patients with latent autoimmu ne diabetes mellitus in adults(LADA)of Han nationality in the northeast a rea of China.Methods.Seventy-nine diabetics of Han natio nality,whose families have resided in the northeast area of China for more than 3generations,we re divided into 3groups:Group 1(22cases of type 2diabetes with mater-nal inheritance history),Group 2(34cases of LADA),Group 3(23cases of type 1diabetes in adolesc ents).The A3243G of mt DNA was detected in th ese 79subjects with the method of PCR-RFLP.Results.None of the 79diabetics studied was p ositively identified for the A3243G mutation of mt DNA.Conclusion.The A3243G mutation of mt DNA might not be related to the onset of LADA in dia betic popula-tion of Han nationality in northeast area of China and there might not be close relationship between A3243G mut a-tion of mt DNA and autoimmunity.
Objective. To identify the A3243G mutation of mi tochondrial (mt) DNA in patients with latent autoimmune diabetes mellitus in adults (LADA) of Han nationality in the northeast a rea of China. Methods. Seventy-nine diabetics of Han natio nality, whose families have resided in the northeast area of China for more than 3generations, we re divided into 3groups: Group 1 (22cases of type 2 diabetes with mater-nal inheritance history), Group 2 (34cases of LADA), Group 3 (23cases of type 1diabetes in adolesc ents). The A3243G of mt DNA was detected in th ese 79subjects with the method of PCR-RFLP. Results. None of the 79 diabetics studied was p ositively identified for the A3243G mutation of mt DNA. Contact. The A3243G mutation of mt DNA might not be related to the onset of LADA in dia betic popula- tion of Han nationality in northeast area of China and there might not be close relationship between A3243G muta- tion of mt DNA and autoimmunity.