论文部分内容阅读
目的:探讨早期肾功能损害诊断中应用尿微量蛋白与血清胱抑素C联合检验的意义。方法:按照随机抽样的方式选择河南省濮阳市精神卫生中心收治的高血压、糖尿病合并早期肾功能损害患者68例作为对象,根据原发病类型分为糖尿病组(40例)、高血压组(28例),纳入时间在2015年1月至2017年1月,同时选择同期接待的健康体检者50例作为对照组,3组研究对象均测定尿微量蛋白与血清胱抑素C,并采取统计学分析3组2种指标水平。结果:糖尿病组患者、高血压组患者在血清胱抑素C、尿微量蛋白水平明显高于对照组,差异具有统计学意义(P<0.05),同时糖尿病组患者前述指标均显著高于高血压组患者,差异具有统计学意义(P<0.05)。结论:早期肾功能损害患者存在尿微量蛋白与血清胱抑素C升高现象,而且原发病为糖尿病患者时这些指标水平要高于原发病高血压患者,需加强重视。
Objective: To investigate the significance of urine microalbumin and serum cystatin C in the diagnosis of early renal dysfunction. Methods: Sixty-eight patients with hypertension and diabetes mellitus complicated with early renal dysfunction admitted to Puyang City Mental Health Center of Henan Province were selected according to random sampling method. According to the type of primary disease, they were divided into diabetic group (40 cases), hypertension group 28 cases) were enrolled in the study period from January 2015 to January 2017. At the same time, 50 healthy subjects who received the same period were selected as the control group. Urinary microalbuminuria and serum cystatin C levels were measured in all three groups and statistics Analysis of three groups of two kinds of indicators. Results: The levels of cystatin C and urine microalbumin in patients with diabetes mellitus and hypertension group were significantly higher than those in control group (P <0.05), and the above indexes in diabetes mellitus patients were significantly higher than those in patients with hypertension Group patients, the difference was statistically significant (P <0.05). CONCLUSIONS: Urine microalbuminuria and serum cystatin C levels are elevated in patients with early renal impairment, and these indicators are higher in patients with primary disease than those with primary disease and need to be emphasized.