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目的分析放疗前贫血对老年食管鳞癌患者放射治疗预后的影响。方法回顾性分析103例年龄≥70岁接受放射治疗的食管鳞癌患者,根据放疗前血红蛋白水平分为贫血组与非贫血组。结果贫血组1、2、3年总生存率(Overall survival,OS)及无病生存率(Disease-free survival,DFS)分别为59.37%、28.15%、6.25%及25.00%、18.75%、6.25%;非贫血组1、2、3年OS及DFS分别为77.46%、46.48%、23.94%及63.38%、35.21%、16.90%,两组间比较差异有统计学意义(P<0.05)。单因素分析结果显示:1、2、3年OS及DFS在血红蛋白、T分期、N分期、M分期、临床分期方面差异有统计学意义(P<0.05)。多因素预后分析结果示:贫血独立于T、N分期影响1、2年OS及DFS,独立于临床分期、N分期影响3年OS及DFS。结论放疗前贫血为影响老年食管鳞癌患者预后的重要因素,其亦可增加复发或转移的风险。
Objective To analyze the influence of anemia before radiotherapy on the prognosis of elderly patients with esophageal squamous cell carcinoma undergoing radiotherapy. Methods A retrospective analysis of 103 patients with esophageal squamous carcinoma who were over 70 years of age undergoing radiotherapy was divided into anemia group and non-anemia group according to hemoglobin level before radiotherapy. Results The overall survival (OS) and disease-free survival (DFS) at 1, 2 and 3 years were 59.37%, 28.15%, 6.25% and 25.00%, 18.75% and 6.25% ; The OS, DFS of 1, 2, 3 years in non-anemia group were 77.46%, 46.48%, 23.94% and 63.38%, 35.21% and 16.90% respectively. There was significant difference between the two groups (P <0.05). Univariate analysis showed that OS, DFS were significantly different in 1, 2 and 3 years (P <0.05) in terms of hemoglobin, T stage, N stage, M stage and clinical stage. Multivariate prognostic analysis showed that anemia independent of T, N stage affects 1 and 2 years OS and DFS, independent of clinical stage, N stage affects 3 years OS and DFS. Conclusion Anemia before radiotherapy is an important factor affecting the prognosis of elderly patients with esophageal squamous cell carcinoma, which may also increase the risk of recurrence or metastasis.