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1948年起Jacobson等用铅板保护脾脏,或通过输入脾细胞或骨髓细胞都可保护受到致死性全身照射的小白鼠免于死亡。进一步实验证实这种保护作用系由于供体细胞在受体骨髓内增殖所致,从而为骨髓移植应用于临床奠定了实验基础。Barnes及Mathe氏等动物实验及临床观察证实,用超致死量~(60)钴1,000拉德作全身照射(简称TBI),然后作骨髓移植可
Since 1948, Jacobson and other lead shields the spleen, or by importing spleen cells or bone marrow cells can protect the fatal whole body irradiation mice from death. Further experiments confirmed that this protective effect is due to the proliferation of donor cells in the recipient bone marrow, which laid the foundation for the clinical application of bone marrow transplantation. Barnes and Mathe and other animal experiments and clinical observations confirmed that with ultra-lethal dose of ~ (60) cobalt 1,000 rad for whole body irradiation (TBI), and then for bone marrow transplantation can be