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治疗缺血性心脏病的药物主要有三类:硝酸酯、β阻滞剂和钙拮抗剂。急性心肌缺血时,硝酸酯、钙拮抗剂通过减少前、后负荷,β阻滞剂通过减少心率和心肌收缩性,使心肌氧耗减低。此外,三药均引起正常心肌和缺血心肌之间的冠状动脉血流重新分布,有些对心肌还有直接保护作用。本文以放射性核素心室造影和左室局部功能定量分析方法比较硝酸甘油、硝苯吡啶和美多心安对静息和运动时正常心肌节段、缺血心肌节段及疤痕节段的即刻影响。
There are three main types of drugs used to treat ischemic heart disease: nitrates, beta blockers, and calcium antagonists. Acute myocardial ischemia, nitrate, calcium antagonist by reducing the before and after the load, β blockers by reducing heart rate and myocardial contractility, myocardial oxygen consumption decreased. In addition, all three drugs cause redistribution of coronary blood flow between normal and ischemic myocardium, and some have a direct protective effect on the myocardium. In this paper, the immediate effects of nitroglycerin, nifedipine and metopronate on normal myocardial segments, ischemic myocardial segments and scar segments at rest and exercise were compared by radionuclide ventriculography and left ventricular local functional quantitative analysis.