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人类血管内皮生长因子(vascular ednothelial growth factor,VEGF)是1989年由Gonnolly从牛垂体滤泡星状细胞体外培养液中首先纯化分离出来,并发现其具有促血管内皮细胞有丝分裂的活性,是作用最强和特异性最高的血管新生调控因子。VEGF不仅在血管内皮细胞中表达,在肿瘤细胞
Human vascular endothelial growth factor (VEGF) was first isolated and purified from bovine pituitary follicular stellate cells in vitro by Gonnolly in 1989 and was found to have the activity of promoting vascular endothelial cell mitosis Strong and specific angiogenesis regulators. VEGF is expressed not only in vascular endothelial cells but also in tumor cells