结核病人458例,使用9种抗结核药治疗,出现不良反应(ADRs)者86例,发生率18.8%,女性发生率(20.8%)稍高于男性(17.1%).不良反应共10种,其频度依次为听力、胃肠、前庭、肝损及过敏反应等.胃肠及过敏反应女性多,男性多见前庭及听力反应,肝损男女相近.各年龄组ADRs发生率14岁以下组最低(14.3%).药物中ADRs频度高的前三位为链霉素、利福平及PAS.链霉素以听力及前庭反应多见,利福平多为肝损,PAS全都出现胃肠反应.ADRs出现时间多在2个月内.ADRs严重程度以轻、中度居多. Among the 458 TB patients treated with 9 kinds of anti-TB drugs, there were 86 cases with ADRs, the incidence rate was 18.8%, the incidence rate of women was 20.8%, slightly higher than that of males (17.1%) .There were 10 kinds of adverse reactions, The frequency was followed by hearing, gastrointestinal, vestibular, liver damage and allergic reactions, etc. Gastrointestinal and anaphylactic reactions were more common in women than in men, and the incidence of vestibular and hearing were more common in men than in men and women with liver damage (14.3%). The top three ADRs in drug were streptomycin, rifampicin and PAS. Streptomycin was more common in hearing and vestibular reaction, rifampicin was mostly liver damage, PAS all had stomach Intestinal reactions.ADRs appear more than 2 months.The severity of ADRs with light and moderate majority.