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在正常和多囊卵巢综合征(PCOS)妇女的月经滤泡期LH和瘦素脉冲分泌是同步的,说明瘦素参与血LH的分泌调节。为了解完全哺乳的正常和PCOS妇女生产后第4和第8周泌乳性闭经时血LH和瘦素的波动情况,以确定在LH脉冲分泌恢复期间LH-瘦素的相互作用进行研究。 孕前诊断PCOS标准为月经稀发或闭经,多毛,血睾酮>0.6nig/ml或游离雄激素指数>5.0,B超下见特征性卵巢形态,LH/FSH比例可正常。所有妇女闭经和不排卵都根据孕酮测定和B超检查来确定。20例PCOS妇女经节食和运动治疗后6例妊娠并足月分娩。平均体质指数(BMI)28.3(25.2～37)ks/m~2,平均年龄24.2(21～33)岁为研究组。选择6例正常哺乳妇女,平均年龄23.8(19～30)岁和平均BM126.7(20.8～30.0)kg/m~2相似,月经周期规则28～32天,无多毛和
In normal and women with PCOS women, menstrual follicular phase LH and leptin pulse secretion are synchronized, indicating that leptin in blood LH secretion regulation. To understand the fluctuations in blood LH and leptin during lactation amenorrhea at 4 and 8 weeks after birth in fully lactated normal and PCOS women to determine the interaction of LH-leptin during LH pulse secretion recovery. Pre-pregnancy diagnostic PCOS criteria for menstrual thinning or amenorrhea, hirsutism, blood testosterone> 0.6nig / ml or free androgen index> 5.0, B ultra-see the characteristic ovarian morphology, LH / FSH ratio can be normal. Amenorrhea and anovulation in all women were based on progesterone and B-ultrasound. Twenty women with PCOS underwent pregnancy and full-term delivery after dieting and exercise. The mean body mass index (BMI) was 28.3 (25.2-37) ks / m ~ 2 and the average age was 24.2 (21-33) years old. The average age of 23.8 (19-30) years was similar to that of the average BM126.7 (20.8-30.0) kg / m ~ 2. The menstrual cycle was 28-32 days with no hirsutism