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Objective:To determine the relationship between the expression of aquaporin-4(AQP4) after intracerebral hemorrhage and dexamethasone treated.Methods:CollagenaseⅦwas injected in caudate nucleus in a stereotaxis frame to establish the intracerebral hemorrhage(ICH) animal models.The intracerebral hemorrhage(ICH) rats were randomly divided into four groups:the sham group (group A),the ICH group(group B),low dose-treated group(group C),moderate dose group(group D) and high dose group(group E). The groups were respectively received an intraperitoneal dexamethasone injection with 1 mg/kg,15 mg/kg,30 mg/kg,twice a day for three days.The brain water content(BWC),the permeability of blood-brain barrier(BBB) and the expression of AQP4 were observed. Results:Both the BBB disruption and AQP4 expression decreased in treated groups,and the AQP4 expression had a dose-dependent manner in the dexamethasone treatment.And it seemed that low dose dexamethasone was in favor of brain swelling elimination,but the higher dosage had not similar effect.Conclusion:Dexamethesone may play a critical role on expression of AQP4 in the physiopathology of hemorrhagic edema.
Objective: To determine the relationship between the expression of aquaporin-4 (AQP4) after intracerebral hemorrhage and dexamethasone treated. Methods: Collagenase VII was injected in caudate nucleus in a stereotaxis frame to establish the intracerebral hemorrhage (ICH) animal models. Intracerebral hemorrhage ) rats were randomly divided into four groups: the sham group (group A), the ICH group (group B), low dose-treated group (group C), moderate dose group (group D) and high dose group (group E) . The groups were respectively received intraperitoneal dexamethasone injection with 1 mg / kg, 15 mg / kg, 30 mg / kg, twice a day for three days. The brain water content (BWC), the permeability of blood- Results: Both the BBB disruption and AQP4 expression decreased in treated groups, and the AQP4 expression had a dose-dependent manner in the dexamethasone treatment. And it was that low dose dexamethasone was in favor of brain swelling elimination, b ut the higher dosage had not similar effect. Confound: Dexamethesone may play a critical role on expression of AQP4 in the physiopathology of hemorrhagic edema.