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目的:本文旨在观察血小板活化因子在急性出血坏死性胰腺炎(AHNP)大鼠肾损伤发生中作用。方法:159只SD大鼠随机分三组:假手术组、AHNP非治疗组和AHNP+BN(52021)治疗祖。采用胰管内注入5％牛磺胆酸钠溶液诱导大鼠AHNP,应用~(86)Rb组织摄取法测定肾脏相对血流量及组织灌注量,并测定血小板聚集率(PAgR)。结果:与非治疗组相比较,BN(52021)治疗组肾脏相对血流量、组织灌注量显著提高;PAgR下降;肾脏病理损害减轻。结论:血小板活化因子参与了急性出血坏死性胰腺炎大鼠肾损害的发生。
Objective: This study aimed to observe the role of platelet activating factor in the development of renal injury in acute hemorrhagic necrotizing pancreatitis (AHNP) rats. Methods: A total of 159 SD rats were randomly divided into three groups: sham operation group, AHNP non-treatment group and AHNP + BN (52021) treatment progenitor. AHNP was induced by intraductal injection of 5% sodium taurocholate into the pancreatic duct. The relative renal blood flow and tissue perfusion were measured with ~ (86) Rb tissue uptake method. The platelet aggregation rate (PAgR) was measured. Results: Compared with non-treatment group, BN (52021) treatment group, renal relative blood flow, tissue perfusion significantly increased; PAgR decreased; renal pathological lesions reduced. Conclusion: Platelet-activating factor is involved in the development of renal damage in rats with acute hemorrhagic necrotizing pancreatitis.