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目的评价不同剂量双环醇对妇科肿瘤化疗药物所致肝损害的预防作用。方法将40例妇科肿瘤病人随机分为对照组、低剂量治疗组、中剂量治疗组、高剂量治疗组,治疗组每日化疗同时加入不同剂量双环醇片保肝治疗,观察连续用药24周后的疗效和安全性。结果治疗组血清氨基转移酶均得到明显下降,且150mg/d治疗组更为明显(P<0.01),未发生明显不良反应。结论双环醇片150mg·d-1在预防妇科肿瘤化疗药物性肝损伤降低血清氨基转氨酶方面优于75mg·d-1,与225mg·d-1相当。
Objective To evaluate the preventive effect of different doses of bicyclol on liver damage induced by chemotherapy drugs in gynecological tumors. Methods 40 cases of gynecologic oncology patients were randomly divided into control group, low-dose treatment group, middle-dose treatment group, high-dose treatment group and treatment group with daily addition of different doses of bicyclol tablets. After 24 weeks of continuous treatment, Efficacy and safety. Results Serum aminotransferase in the treatment group was significantly decreased, and 150mg / d treatment group was more obvious (P <0.01), no significant adverse reactions. Conclusion Bicyclol 150 mg · d-1 is superior to 225 mg · d-1 in preventing the decrease of serum aminotransferase in chemotherapy-induced liver injury induced by gynecologic tumor.