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目的 :探讨支气管哮喘与内皮素 - 1 (ET - 1 )的关系 ;方法 :采用放射免疫法测定2 0例健康人和 36例支气管哮喘病人发作期与缓解期血浆ET - 1水平 ;结果 :轻度发作组发作期与缓解期相比无明显差异 (P >0 0 5 ) ;中度发作组与缓解期比明显升高 (P <0 0 5 ) ;重度发作期与缓解期比亦显著升高 (P <0 0 1 ) ;结论 :支气管哮喘发作期血浆ET - 1明显升高 ,且与病情程度相一致
Objective: To investigate the relationship between bronchial asthma and endothelin - 1 (ET - 1). Methods: Radioimmunoassay was used to detect plasma ET - 1 levels in 20 healthy subjects and 36 patients with bronchial asthma. Results: There was no significant difference between the seizure group and the remission (P> 0.05), the moderate seizure group and remission ratio were significantly higher (P <0.05), and the severity of seizures and remission period were also significantly increased (P <0.01). Conclusion: ET - 1 in bronchial asthma exacerbation significantly increased, and consistent with the severity of the disease