大黄力瘳科类草本植物,气味寒苦,它具有泻下,抗菌,抗肿瘤,抗高脂血症,降低血压,健胃,利胆,保肝,调节免疫等作用。现将大黄的临床用途分析报告如下。 抗精神病作用:大黄抗精神病的有效成分是鞣质。用大黄水浸液50mg/kg给大鼠灌胃,其探索行为受到抑制,而且作用程度与药物剂量呈正相关。给小鼠腹腔注射2mg/kg的大黄鞣质,小鼠探索行为受抑制程度强于氯丙嗪。大黄水煎液和大黄鞣质均能抑制甲基苯丙氨诱发的大鼠的自发运动亢进,降低摘除双侧嗅球大鼠对抗攻击性和捕获性进行抵抗的能力。另外,大黄在抑制阿朴吗啡诱发的常见行为、抗去甲肾上腺素致死作用、抗条件回避反应等方面与常用的抗精神病药 Rhubarb is a family of herbaceous plants of the family Fructus. Its smell is cold and bitter. It has diarrhea, antibacterial, anti-tumor, anti-hyperlipidemia, lower blood pressure, stomach, gallbladder, liver protection, immune regulation and so on. The clinical use of rhubarb is now reported as follows. Antipsychotic effects: The active ingredient of rhubarb antipsychotics is tannins. The rats were given intragastric administration of Rhubarb water extract at a dose of 50 mg/kg, their exploration behavior was inhibited, and the degree of action was positively correlated with the drug dose. Mice were intraperitoneally injected with 2 mg/kg rhubarb tannins. The mice exhibited stronger inhibition of quest behavior than chlorpromazine. Both rhubarb decoction and rhubarb tannin can inhibit the spontaneous hyperkinesis of rats induced by methamphetamine, and reduce the ability of the bilateral olfactory bulbs to resist the resistance to attack and capture. In addition, rhubarb is commonly used as an antipsychotic agent in inhibiting apomorphine-induced common behavior, anti-norepinephrine lethal effect, and anti-condition avoidance response.