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目的对异常孕产史孕妇在B超引导下的羊膜腔穿刺术行产前诊断的安全性及有效性进行评估,分析孕妇的妊娠结局。方法回顾性分析我院产前诊断中心2012年1月至2013年9月异常孕产史孕妇在B超引导下的羊膜腔穿刺病例271例,对羊水细胞染色体产前诊断结果、流产率及妊娠结局进行分析。结果发现异常核型19例,异常核型检出率7.01%,其中数目异常9例,占染色体异常核型47.3%,结构异常10例,占染色体异常核型的,52.63%。培养失败1例。术后1个月内流产1例,羊水诊断结果正常的孕妇在以后的孕检中,超声发现胎儿畸形2例,引产终止妊娠。结论异常孕产史孕妇做羊水诊断检查是安全、有效的方法,可及时发现染色体异常胎儿,减少出生缺陷儿的产生。
Objective To evaluate the safety and efficacy of prenatal diagnosis of amniocentesis under the guidance of B-ultrasound in pregnant women with abnormal history of pregnancy and to analyze the pregnant outcome of pregnant women. Methods A retrospective analysis of 271 cases of amniocentesis by pregnant women undergoing B-mode ultrasound in prenatal diagnosis center of our hospital from January 2012 to September 2013 was conducted. The results of prenatal diagnosis, abortion rate and pregnancy The outcome is analyzed. The results showed that there were 19 abnormal karyotypes and 7.01% of abnormal karyotypes, of which 9 were abnormal in number, accounting for 47.3% of chromosomal abnormalities and 10 of structural abnormalities, accounting for 52.63% of chromosomal abnormal karyotypes. One case failed to cultivate. Abortion in 1 month after surgery in 1 case, the normal diagnosis of amniotic fluid in pregnant women in the subsequent pregnancy test, ultrasound found 2 cases of fetal malformation, abortion termination of pregnancy. Conclusion Abortion history of pregnant women do amniotic fluid diagnostic test is a safe and effective way to detect fetal chromosomal abnormalities in a timely manner to reduce the birth of children with birth defects.