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在常规应用维生素K_1以前,荷兰新生儿出血性疾病的发病率为1:8000。在1990年底,荷兰儿科学会提出了新生儿维生素K_1使用方案,但此方案缺乏科学依据。因此荷兰学者Hogen—birk等人采用安慰剂对照随机双盲方法研究了母乳喂养、人工喂养和出生时给一剂维生素K_1对新生儿维生素K_1及其有关凝血因子血浓度的影响。选妊娠37～42周分娩、出生体重>2500g
The incidence of neonatal hemorrhagic disease in the Netherlands was 1: 8000 before routine use of vitamin K_1. At the end of 1990, the Dutch Pediatric Society proposed the use of vitamin K 1 in neonates, but this program lacks scientific evidence. Therefore, the Dutch scholar Hogen-birk et al placebo-controlled randomized double-blind study of breast-feeding, artificial feeding and birth to a vitamin K_1 on neonatal vitamin K_1 and its related blood coagulation factor blood concentration. 37-42 weeks of pregnancy delivery, birth weight> 2500g