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本文对八十年代以来1000例手术切除肝细胞癌的临床病理特点进行了分析。结果:(1)男性肝癌患者的年龄高峰在50岁,女性肝癌患者在40岁,但均从30岁起急剧增多,(2)无肝硬变肝癌中75.3％呈血清HBsAg阳性,提示此类肝癌仍以HBV为主要致癌因素,但感染方式可能不同于肝硬变肝癌;(3)肝癌患者血清AFP含量呈哑铃型分布特征,与瘤体大小、有无肝硬变以及肝癌分化程度无明显关系;(4)肝癌术后复发与首次切除肝癌的瘤体大小有关,与是否伴肝硬变无关;(5)3cm以下小肝癌仅占肝癌的10.2％,术后5年生存率为82.4％,高于总体肝癌的27.5％。认为提高肝癌患者生存率的关键是提高3cm以下小肝癌的诊治率。
This article analyzes the clinicopathological features of 1000 surgical resections of hepatocellular carcinoma since the 1980s. Results: (1) The age of male patients with hepatocellular carcinoma was 50 years old and female hepatocellular carcinoma patients were 40 years old, but all of them increased rapidly from the age of 30. (2) 75.3% of liver cancer patients without liver cirrhosis showed serum HBsAg positive, suggesting that HBV is still the main carcinogenic factor in liver cancer, but the infection may be different from liver cirrhosis; (3) The serum AFP content in patients with liver cancer is dumbbell-shaped, and the tumor size, presence of liver cirrhosis and differentiation of liver cancer are not obvious. Relationship; (4) Recurrence of hepatocellular carcinoma is related to the size of the tumor in the first resection of liver cancer, and has nothing to do with whether it is associated with cirrhosis; (5) Small hepatocellular carcinoma below 3cm only accounts for 10.2% of liver cancer, postoperative 5-year survival rate is 82.4% , higher than 27.5% of the total liver cancer. The key to improving the survival rate of liver cancer patients is to improve the diagnosis and treatment rate of small hepatocellular carcinoma below 3 cm.