关于化学物对男性生殖功能的影响,近年来日益受到人们重视。Whorton等(1977)首次报道接触二溴氯丙烷(DBCP)的男性工人精子缺乏和不育。嗣后,又有许多类似的报道。迄今,已发现不少化学物能引起男性生殖功能障碍。评价化学物对男性生殖毒性的方法较为复杂,流行病学调查是其中一个非常重要的方面。这里,仅就男性生殖毒物的流行病学评价中的几个问题作一简要介绍和讨论。一、男性生育史评价长期接触生殖毒物可影响生殖能力。已婚男性工人的生殖能力异常,可表现为性欲减退和阳萎,配偶受孕率和生育率降低,自发性流 The effect of chemicals on male reproductive function has been paid more and more attention in recent years. For the first time, Whorton et al. (1977) reported male workers exposed to dibromochloropropane (DBCP) lacking sperm and infertility. Later, there are many similar reports. To date, many chemicals have been found to cause male reproductive dysfunction. The methods used to evaluate the reproductive toxicity of chemicals to men are complex and epidemiological surveys are one of the most important aspects. Here, only a brief description and discussion of several issues in the epidemiological evaluation of male reproductive toxicants. First, the male reproductive history evaluation of long-term exposure to reproductive toxicants can affect reproductive capacity. Married male workers reproductive abnormalities, can be expressed as loss of libido and impotence, spouse pregnancy rate and fertility decreased, spontaneous flow