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对氨柳酸钠(PAS)目前国内常用均为胃溶衣片剂,由于服药后出现胃肠反应较多,常被迫停用。因PAS含有结晶水,胃溶衣片剂潮湿性较大,夏季储存常遇片剂裂口,为减少副作用及防裂口,天津市力生制药厂把胃溶衣片改成为肠溶衣片。我们对这两种糖衣片对结核病人进行服药后的血药浓度测定和服药一疗程(3个月)的临床观察,结果简述如下: 一、血药浓度测定采用直立扩散生物法,测定每毫升血液中含PAS的微克数。 (一)对象:内、外科住院结核病人,胃溶衣PAS组(以下简称为胃组)45人分别在服药后1、
Right sodium salicylate (PAS) are commonly used in the domestic stomach dissolved tablets, due to gastrointestinal reactions after taking more often forced to stop. Due to the PAS contains water of crystallization, stomach dissolve tablets dampness larger, often encountered in summer storage tablets cracks, in order to reduce the side effects and anti-cracking mouth, Tianjin Lisheng Pharmaceutical Factory to enteric-coated tablets. We have these two kinds of sugar-coated tablets of tuberculosis patients after taking blood concentration determination and taking a course of treatment (3 months) of clinical observations, the results are summarized as follows: First, the determination of plasma concentration using upright diffusion bioassay, each measured Ml blood PAS containing micrograms. (I) Subjects: In-patients and surgical patients with tuberculosis in hospital, stomach-dissolving PAS group (hereinafter referred to as stomach group), 45 were taken after taking medicine 1,