基因治疗成为近年来肿瘤治疗研究的热点之一。目前常用的基因治疗方法主要有:抑癌基因治疗、抗血管生成基因治疗、自杀基因治疗、免疫基因治疗、修饰基因治疗及溶瘤病毒治疗等[1]。本文就目前研究较多、发展较快的有关溶瘤病毒基因治疗研究进展综述如下。1溶瘤病毒种类近年来将 Gene therapy has become one of the hot spots in cancer therapy in recent years. The commonly used gene therapy methods are: tumor suppressor gene therapy, anti-angiogenic gene therapy, suicide gene therapy, immune gene therapy, modified gene therapy and oncolytic virus therapy [1]. This article on the current more research, rapid development of oncolytic virus gene therapy research progress are summarized below. 1 oncolytic virus species will be in recent years