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体内外疟原虫获得性免疫作用机理研究表明,保护性抗体并不影响细胞内原虫,而只影响裂殖子释放至血浆中的这一生活史阶段,并且免疫血清可凝集游离裂殖子,阻止裂殖子与悬浮红细胞受体相结合。因此,有必要对鼠伯氏疟原虫(Plasmodium berghei)裂殖子、红内期全虫可溶性抗原主动免疫的保护作用进行实验观察。我们于1990年12月～1991年3月进行了此工作,结果报告如下。一、材料与方法 (一)实验动物和疟原虫NIH小白鼠为实验动物,系本所饲养.引自中国预防医学科学院寄生虫病研究所的伯氏疟原虫ANKA株为实验原虫。 (二)裂殖子抗原感染血加3～5倍量磷酸缓冲
Studies on the mechanism of acquired immunity in vitro and in vivo of malaria parasites show that protective antibodies do not affect intracellular protozoa but affect the release of merozoites to this phase of life history in plasma and immune sera can agglutinate free merozoites and prevent Mecones and suspended erythrocyte receptor binding. Therefore, it is necessary to experimentally observe the protective effect of active immunity of soluble antigen of Plasmodium berghei in merozoites and erythrocytes. We conducted this work from December 1990 to March 1991 and the results are reported below. I. Materials and methods (1) Experimental animals and Plasmodium NIH mice were fed on the laboratory and were bred from the ANKA strain of Plasmodium berghei of the Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine. (B) merozoite antigen blood plus 3 to 5 times the amount of phosphate buffered