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为探索全营养混合液（ＴＮＡ）经周围静脉应用合理性及了解脂肪乳剂在ＴＮＡ液中的稳定性，测定了肠外营养液中各营养成分和按临床应用不同营养液配比的ｐＨ、渗透压；另用透视电镜观察脂肪乳剂在ＴＮＡ中的颗粒大小、形态变化。结果显示：ｐＨ除１０％脂肪乳剂为７．３８外，余均在５．１６～６．６７；渗透压除脂肪乳剂为等渗外，余均为高澎液。将所有营养成分按临床应用比例混合后，其ｐＨ为６．２０～６．３０，渗透压１６２４，５８～１９３４．０３ｋＰａ。脂肪乳剂混合前平均颗粒直径为０．４μｍ，脂肪乳剂加入ＴＮＡ２４小时后，平均直径０．３５μｍ，颗粒完整，但与５％氯化钙或５０％葡萄糖混合２４小时后，颗粒直径达０．９μｍ，颗粒形态异常。按一定程序配制混合营养液，临床应用１０００人次，未见不良反应。
In order to explore the rationality of application of TNA through peripheral vein and to understand the stability of fat emulsion in TNA solution, the relationship between nutrition composition in parenteral nutrition solution and different nutrient solutions according to clinical application was determined. Pressure; the other with the perspective of electron microscope observation of fat emulsion in TNA particle size, morphological changes. The results showed that the pH was 5.16 ~ 6.67 except that 10% fat emulsion was 7.38, while the osmotic pressure removal fat emulsion was isotonic, except for Gao Peng liquid. After all the nutrients are mixed according to the clinical application ratio, the pH value is 6.20 to 6.30 and the osmotic pressure is 1624 and 58 to 1934.03 kPa. The average particle diameter of the fat emulsion before mixing was 0.4 μm, the fat emulsion was TNA 24 hours after addition of TNA, the average diameter was 0.35 μm, the particles were intact, but after mixing with 5% calcium chloride or 50% glucose for 24 hours, the particle diameter was 0.9 μm , Abnormal particle morphology. Prepared by a certain process mixed nutrient solution, clinical application of 1,000 people, no adverse reactions.