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目的探讨血液灌流联合血液透析治疗重度急性中毒的疗效及临床分析。方法 2010年6月至2012年6月期间,我院诊治的62例重度急性有机磷中毒患者,随机将其分为对照组(常规对症处理)和观察组(对照组基础上,进行血液灌流联合血液透析治疗),每组各31例,对两组患者的阿托品用量、患者清醒时间、胆碱酯酶活性恢复时间,以及病死率,进行观察和比较。结果与对照组相比,观察组的阿托品用量明显减少,患者清醒时间和胆碱酯酶活性恢复时间均明显缩短,死亡率明显降低,P<0.05,差异有统计学意义。结论对于重度急性有机磷中毒患者,血液灌流联合血液透析治疗具有疗效显著,患者恢复快等特点,值得临床广泛推广。
Objective To investigate the efficacy and clinical analysis of hemoperfusion combined with hemodialysis in the treatment of severe acute poisoning. Methods From June 2010 to June 2012, 62 patients with severe acute organophosphorus poisoning who were diagnosed and treated in our hospital were randomly divided into control group (conventional symptomatic treatment) and observation group (control group based on the combination of hemoperfusion Hemodialysis treatment), 31 cases in each group. The amounts of atropine, awake time, recovery time of cholinesterase activity and mortality were compared between the two groups. Results Compared with the control group, the amount of atropine in the observation group was significantly reduced, the recovery time of patients’ awake time and the recovery time of cholinesterase were significantly shortened, and the mortality rate was significantly decreased (P <0.05). The difference was statistically significant. Conclusion For patients with severe acute organophosphate poisoning, hemoperfusion combined with hemodialysis has the characteristics of significant curative effect and rapid recovery of patients, which is worthy of widespread clinical application.