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为了探讨恶性肿瘤患者外周血细胞的生物学特性变化的临床意义，作者用流式细胞术对８４例恶性肿瘤患者血细胞凋亡水平进行了检测分析。结果表明，肿瘤患者细胞凋亡水平显著高于健康人（分别为５．５１％±８．５２％和０．２５％±０．２８％，Ｐ＜０．０１）；患者细胞凋亡水平虽然随Ｓ期细胞增高有逐渐减低的趋势，但无明显的线性关系。ＤＮＡ异倍体患者凋亡水平虽然低于二倍体患者，但无统计学意义（Ｐ＞０．０５）。这表明，恶性肿瘤患者外周血细胞凋亡水平变化不仅代表恶性肿瘤一种生物学特性，而且还可以作为恶性肿瘤诊断的良好指标。最后对患者外周血细胞中出现凋亡的原因作了分析。
In order to investigate the clinical significance of changes in the biological characteristics of peripheral blood cells in patients with malignant tumors, the authors used flow cytometry to detect the blood cell apoptosis in 84 patients with malignant tumors. The results showed that the apoptosis level of tumor patients was significantly higher than that of healthy individuals (5.51%±8.52% and 0.25%±0.28%, respectively, P<0.01); With the increase of S phase cells, there is a trend of gradual decrease, but no obvious linear relationship. Although the level of apoptosis in patients with DNA aneuploidy was lower than that in diploid patients, it was not statistically significant (P>0.05). This shows that changes in peripheral blood cell apoptosis in patients with malignant tumors not only represent a biological characteristic of malignant tumors, but also can serve as a good indicator of the diagnosis of malignant tumors. Finally, the causes of apoptosis in peripheral blood cells were analyzed.