早孕引产一般都采用吸引刮宫术,但易产生并发症,如子宫穿孔和宫颈破裂等。用前列腺素F_(2α)和E_2作为早孕引产药物,但因有严重的全身性副作用和并发症,临床上也不欢迎。 Sulprostone为一种新的前列腺素E_2衍生物。在几种动物的体内试验中,引产效果较PGE_2约高10～20倍,而对各种器官的功能无影响或影响较小。本文报道在静脉滴注给药时,对早孕的引产效果。研究对象为166名怀孕5～12周的妇女,平均年龄25.2±6.4岁。其中119名为未产妇而47名为经产妇。将Sulprostone研细后溶于0.9%的氯化钠溶液中,配成1微克/毫升浓度。以不同速度及时间 Early labor induced abortion are generally used to attract curettage, but easy to produce complications, such as uterine perforation and cervical rupture. With prostaglandin F_ (2α) and E_2 as early pregnancy induced labor drugs, but because of serious systemic side effects and complications, clinically not welcome. Sulprostone is a new prostaglandin E 2 derivative. In several animal in vivo tests, induction of labor is about 10 to 20 times higher than that of PGE2, but has no or little effect on the function of various organs. This article reports the induction of labor in early pregnancy when administered intravenously. The study population was 166 women aged 5 to 12 weeks, with an average age of 25.2 ± 6.4 years. 119 were not mothers and 47 were mothers. Sulprostone was finely ground and dissolved in 0.9% sodium chloride solution to give a concentration of 1 μg / ml. With different speed and time