论文部分内容阅读
目的 :研究原发性高血压患者大动脉粥样斑块、内皮功能与内皮素 1和C 反应蛋白的关系。 方法 :选择 10 9例原发性高血压患者 ,其中男性 5 6例 ,女性 5 3例 ,平均年龄 (60 8± 6 2 )岁。应用B型超声对所有病例颈动脉、肱动脉进行扫查 ,检测颈动脉内膜中层厚度 (IMT)及粥样斑块 ,在静息、反应性充血时分别测量肱动脉内径 ,用免疫学方法测定血液中内皮素 1、C 反应蛋白浓度。然后分析超声结果与内皮素 1、C 反应蛋白浓度的关系。 结果 :随着IMT增厚 ,内皮素 1、C 反应蛋白浓度亦增大 ,各组之间差异均有显著性 (P <0 0 1) ,粥样斑块 1、 2、3级内皮素 1、C 反应蛋白浓度高于粥样斑块 0级 (P <0 0 5 )。加压充血后 ,肱动脉管径的内皮依赖性血管扩张(Flow MD)与内皮素 1、C 反应蛋白浓度呈负相关 ,相关系数分别是 -0 62 7、 -0 693 (P <0 0 0 1)。 结论 :原发性高血压患者血液中内皮素 1、C 反应蛋白浓度增高与肱动脉内皮细胞功能受损、颈动脉粥样硬化关系密切。
OBJECTIVE: To study the relationship between atherosclerotic plaque and endothelial function and endothelin 1 and C-reactive protein in patients with essential hypertension. Methods: A total of 109 patients with essential hypertension were selected, including 56 males and 53 females, with an average age of 60 8 ± 6 2 years. In all cases, carotid artery and brachial artery were scanned by B-mode ultrasound, carotid artery intima-media thickness (IMT) and atherosclerotic plaque were detected. The brachial artery diameter was measured at resting and reactive hyperemia. Immunological method Determination of blood endothelin 1, C-reactive protein concentration. Then analyze the relationship between ultrasound results and endothelin 1, C-reactive protein concentration. Results: With the thickening of IMT, the concentration of endothelin 1 and C-reactive protein also increased, with significant difference between the groups (P <0.01), and 1, 2, 3 endothelin 1 C reactive protein was higher than that of atherosclerotic plaques (P <0 05). After pressure hyperemia, the endothelium-dependent vasodilation of the brachial artery (Flow MD) was negatively correlated with the concentration of endothelin-1 and C-reactive protein, with correlation coefficients of -0 627 and -0 693 (P <0 0 0 0 1). Conclusion: The increase of ET-1 and C-reactive protein in the blood of patients with essential hypertension is closely related to the impaired brachial artery endothelial function and carotid atherosclerosis.