人类及大鼠血液中酮体浓度对生理状况的改变非常敏感。血液酮体浓度的改变能够直接影响体内的物质代谢。已经证实,酮体能降低葡萄糖的利用,能抑制脂肪分解,能降低血液丙氨酸的浓度,能刺激胰岛β细胞分泌胰岛素。酮体对蛋白质代谢的影响,尚无定论。为此,我们研究了浓度为2mM、4mM、6mM的D,L-β-羟丁酸对饥饿大鼠膈肌蛋白质分解代谢及谷丙转氨酶活力的影响(用酪氨酸作为衡量肌肉蛋白质代谢状况的指标)。 Ketone concentrations in human and rat blood are very sensitive to changes in their physiology. Changes in the concentration of blood ketone body can directly affect the body’s metabolism. It has been shown that ketones reduce glucose utilization, inhibit lipolysis, decrease blood alanine levels, and stimulate islet β-cells to secrete insulin. The effect of ketone bodies on protein metabolism is inconclusive. To this end, we investigated the effect of D, L-beta-hydroxybutyrate at 2 mM, 4 mM, 6 mM on the protein catabolism and alanine aminotransferase activity in diaphragmatic muscle of starved rats (tyrosine was used as a measure of muscle protein metabolism index).