他汀类药被广泛用于降低胆固醇,但近来的实验室及临床研究发现,他汀类药物用于慢性心力衰竭治疗,可延缓慢性心力衰竭进展,改善心功能,降低慢性心力衰竭致残率、死亡率。他汀类药物治疗慢性心力衰竭的机制与改善血管内皮功能、抗氧化应激、抗炎、改善心肌重构、调节神经及内分泌的“多重效应”有关。 Statins are widely used to lower cholesterol, but recent laboratory and clinical studies found that statins for chronic heart failure can delay the progression of chronic heart failure, improve cardiac function, reduce the rate of disability and death of chronic heart failure rate. The mechanism of statins in the treatment of chronic heart failure is related to the “multiple effects” of improving vascular endothelial function, anti-oxidant stress, anti-inflammatory, improving myocardial remodeling, and regulating nerves and endocrine.