目的:探讨他汀类与贝特类药物联合应用的安全性。方法:病例选择:120例病例均为混合性高脂血症,最小年龄45岁,最大年龄75岁,用药前肝肾功能正常。用法:辛伐他汀(京必舒新)20mg,每晚一次,口服,非诺贝特0.1,每日三次,口服,疗程四周。结果:120例病例出现左肩肌肉轻度酸沉1例;谷丙转氨酶轻度升高5例;谷丙转氨酶显著升高2例,余均无不良反应,用药前后肝肾功能正常。结论:小剂量他汀类与贝特类药物联合应用是安全的。 Objective: To investigate the safety of combination of statins and fibrates. Methods: Case selection: 120 cases were mixed hyperlipidemia, the youngest age of 45 years, the maximum age of 75 years old, liver and kidney function before treatment is normal. Usage: Simvastatin (Beijing will be Shu new) 20mg, once night, orally, fenofibrate 0.1, three times daily, oral, treatment for four weeks. Results: In 120 cases, one case had left shoulder muscle mild acidosis, 5 cases had mildly elevated alanine aminotransferase, 2 cases had a significant increase in alanine aminotransferase, and the others had no adverse reaction. Before and after treatment, liver and kidney function were normal. Conclusion: Small doses of statins combined with fibrates are safe.