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目的探讨影响宫颈癌根治术预后的临床病理及生物学因素。方法收集2003年2月至2009年4月间120例行广泛性全子宫切除+双侧盆腔淋巴结切除术患者的临床资料和宫颈癌石蜡标本,随访3年观察其生存情况,同时进行临床病理及生物学因素分析。结果 120例患者的3年存活率为79.2%。单因素分析显示,临床分期、病理分化程度、淋巴结转移、HuR蛋白阳性表达、VEGF蛋白阳性表达、COX-2蛋白阳性表达与预后相关(P<0.05)。多因素分析确定影响宫颈癌手术预后最显著的独立因素为分化程度和血管内皮生长因子(VEGF)蛋白阳性表达(P<0.05)。结论宫颈癌患者采用根治术生存率比较高,而分化程度与VEGF蛋白阳性表达是影响宫颈癌手术预后的最显著独立因素。
Objective To investigate the clinicopathological and biological factors influencing the prognosis of cervical cancer radical surgery. Methods Clinical data of 120 patients with extensive hysterectomy and bilateral pelvic lymph node dissection from February 2003 to April 2009 were collected and the cervical paraffin specimens were collected. The patients were followed up for 3 years to observe their survival. At the same time, their clinical pathology, Biological factors analysis. Results The three-year survival rate of 120 patients was 79.2%. Univariate analysis showed that the clinical stage, histological grade, lymph node metastasis, HuR protein expression, VEGF protein expression and COX-2 protein expression were positively correlated with prognosis (P <0.05). Multivariate analysis identified the most significant independent factors influencing the prognosis of cervical cancer as the differentiation and the positive expression of VEGF protein (P <0.05). Conclusion The survival rate of patients with cervical cancer by radical surgery is relatively high, while the differentiation and the positive expression of VEGF protein are the most significant independent factors affecting the prognosis of cervical cancer.