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Wistar大鼠随机分3组，每天组予环磷酰胺组（CP）8mg／kg·d×4W，ip；冲击组予CP56mg／kg·d×4W，ip；对照组予生理盐水1ml／d×4W，ip。结果：①睾丸生精细胞损伤：每日组重于冲击组；②血睾酮（T）含量每日组显著低于冲击组（P＜0．05）；冲击组与对照组无显著差异（P＞0．05）。③对睾丸间质细胞的影响：冲击组轻于每日组；④血FSH、LH含量与垂体重量：每日组与冲击组皆正常；⑤血BUN、Cr水平：3组皆正常．说明CP冲击疗法对睾丸间质细胞损伤较轻；CP除直接损伤睾丸组织外，可能还对下丘脑—垂体—睾丸轴有抑制作用．
The Wistar rats were randomly divided into 3 groups. Each group was treated with cyclophosphamide (CP) 8mg / kg · d × 4W, ip. The rats in the impact group were treated with CP56mg / kg · d × 4W, ip. 4W, ip. Results: ① Testicular spermatogenic cell damage: the daily group was heavier than the impact group; ② The content of blood testosterone (T) in the daily group was significantly lower than that in the impact group (P <0.05); The impact group was not significantly different from the control group > 0.05). ③ on the testicular interstitial cells: the impact group lighter than the daily group; ④ blood FSH, LH content and pituitary weight: the daily group and the impact group were normal; ⑤ blood BUN, Cr levels: 3 were normal. CP shock therapy on leydig cells damage less; CP in addition to direct damage to the testicular tissue may also inhibit the hypothalamus - pituitary - testis axis.