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目的:研究乙肝免疫标记物(HBV-M)与乙肝病毒脱氧核苷酸(HBV-DNA)载量与肝功能的关系。方法:检测104例乙肝患者HBs Ag、HBe Ag、HBc Ab、HBs Ab、HBe Ab5种HBV-M;用PCR法检测HBV-DNA含量;同时检测天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、胆碱酯酶(CHE)等肝功能指标,对三者关系采用Spearman相关性分析。结果:HBs Ag、HBc Ab、HBe Ag阳性组HBV-DNA阳性率及载量均大于其余组(P<0.05);HBe Ag含量、ALT浓度与HBV-DNA载量均呈正相关(r=0.48,P<0.05)、(r=0.36,P<0.05);AST、CHE与HBV-DNA含量无明显相关性,但在无病毒载量与有病毒载量组之间AST比较有统计学意义(P<0.05)。结论:HBV-M、HBV-DNA与肝功能之间有一定的相关性,但HBe Ag阴转不代表病毒复制停止,HBV-DNA也不能完全反应肝损害程度,临床应加大重视。
Objective: To study the relationship between hepatitis B immune marker (HBV-M) and hepatitis B virus deoxynucleotidyl transferase (HBV-DNA) load and liver function. Methods: The HBV-M of HBsAg, HBe Ag, HBc Ab, HBs Ab and HBe Ab were detected in 104 cases of hepatitis B patients. The levels of HBV DNA were detected by PCR. The levels of aspartate aminotransferase (AST) Acid aminotransferase (ALT), cholinesterase (CHE) and other liver function indicators, Spearman correlation analysis of the relationship between the three. Results: The positive rate of HBV-DNA and the load of HBsAg, HBcAb and HBeAg positive groups were higher than those of the other groups (P <0.05). HBeAg and ALT concentrations were positively correlated with HBV-DNA load (r = 0.48, There was no significant correlation between AST, CHE and HBV-DNA levels, but there was significant difference between the viral load-free group and the viral load group (P <0.05) (P = 0.36, P <0.05) <0.05). Conclusion: The correlation between HBV-M, HBV-DNA and liver function has a certain correlation, but HBe Ag overcast does not mean that virus replication stops, HBV-DNA can not fully reflect the degree of liver damage, clinical should pay more attention.