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前列腺环素是花生四烯酸的不稳定代谢产物,具有较强的血小板聚集抑制作用。血管壁不断合成并释放少量前列腺环素,防止血小板聚集物沉积在血管壁表面。因此,它对于防止血栓形成和动脉粥样硬化是一个重要因素。动物试验证明,口服Bay g6575具有减少或防止动、静脉血栓形成的作用。 6名受试者每日口服Bayg6575 1200毫克后,对纤维蛋白元水平、凝血因子Ⅷ生物活性、凝血因子Ⅷ抗原水平、优球蛋白溶解时间、凝血弹性描记指数均无影响。体外试验对A.D.P.等引起的血小板聚集无抑制作用,但体内试验则有抑制作用。 5名口服Bay g6575受试者的血浆,能刺
Prostacyclin is an unstable metabolite of arachidonic acid, with strong inhibition of platelet aggregation. Continuous synthesis of the vessel wall and the release of a small amount of prostacyclin to prevent the deposition of platelet aggregates in the vessel wall surface. Therefore, it is an important factor in preventing thrombosis and atherosclerosis. Animal experiments show that oral Bay g6575 has the role of reducing or preventing arterial and venous thrombosis. Six subjects had no effect on fibrinogen levels, creatinine Ⅷ activity, factor Ⅷ antigen level, euglobulin lysis time, and thromboelastography index after oral administration of 1200 mg of Bayg6575 daily. In vitro tests on A.D.P. platelet aggregation caused by no inhibitory effect, but in vivo test has inhibitory effect. Plasma of 5 oral Bay g6575 subjects stabbed