B细胞是人体在生理状态下唯一可以发生体细胞高频突变的场所,而这一过程正是B细胞产生高效抗体的过程。近日,科学家通过在硅载体上的研究发现了可以产生HIV高亲和力抗体的方法。相关研究结果发表于国际生命科学顶尖杂志Cell上。抗体是由成熟的B细胞或记忆性B细胞分化成浆细胞后分泌产生的免疫球蛋白,可以特异性地结合相应的抗原。亲和力成熟是指浆细胞内 B cells are the only places where human body can produce high frequency of somatic mutation in physiological state, and this process is precisely the process by which B cells produce high efficiency antibody. Recently, scientists have found on the silicon carrier that high-affinity HIV antibodies can be produced. Relevant research results published in the top international life science magazine Cell. Antibodies are immunoglobulins produced by the differentiation of mature B cells or memory B cells into plasma cells and bind specifically to the corresponding antigen. Affinity maturity refers to plasma cells