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器官移植是当器官发生不可逆衰竭时的治疗方法之一。1986年美国进行了9000例肾移植,1427例心移植,900例肝移植及少量的心-肺移植和多器官移植。目前由于环孢菌素免疫抑制性质的发现和应用,环孢菌素、甾体类与硫唑嘌呤低剂量的联合疗法,以及适当地应用抗T-3淋巴细胞单克隆抗体,使移植病人的一年存活率明显提高,其中肾95%,心78%,肝70%。在移植病人中药物疗法的优化是一个难题。因病人需长期使用各种免疫抑制剂、抗高血压药、抗生素、抗霉菌药、抗病毒药和其它药物,包括各种免疫抑制剂的组合以及减轻环孢菌素肾毒性的措施。
Organ transplantation is one of the treatment options when an organ has irreversibly failed. In 1986, the United States conducted 9,000 kidney transplants, 1,427 heart transplants, 900 liver transplants and a small number of heart-lung transplants and multiple organ transplants. Due to the discovery and application of the immunosuppressive properties of cyclosporins, cyclosporin, low dose combination of steroids and azathioprine, and the appropriate use of anti-T-3 lymphocyte monoclonal antibody, One year survival rate was significantly improved, of which 95% of the kidneys, heart 78%, liver 70%. Optimization of drug therapy in transplant patients is a challenge. The long-term use of various immunosuppressive agents, antihypertensives, antibiotics, antimycotics, antivirals and other drugs, including combinations of various immunosuppressive agents, and measures to reduce cyclosporin nephrotoxicity due to long-term use by patients.