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目的检测生活在佛山市内反复喘息婴幼儿血清25-羟维生素D3[25-(OH)Vit D3]、白介素-10(IL-10)、免疫球蛋白E(Ig E)水平与当地正常健康体检儿进行比较,探讨其临床意义。方法 25例反复喘息婴幼儿作为研究组,同期25例健康体检儿作为对照组,全部对象均检测血清25-(OH)Vit D_3、IL-10及Ig E水平。观察比较两组水平差异。结果研究组血清25-(OH)Vit D3水平为(48.26±14.36)nmol/L低于对照组的(89.77±14.36)nmol/L,IL-10为(24.11±6.52)pg/ml低于对照组的(43.26±10.21)pg/ml,Ig E水平为(165.50±23.47)IU/ml明显高于对照组的(116.13±12.18)IU/ml,差异有统计学意义(P<0.05)。结论低纬度的佛山地区的反复喘息婴幼儿同样存在维生素D(Vit D)缺乏情况,补充Vit D可能是预防喘息反复发作的综合因素之一。
Objective To detect serum 25-hydroxyvitamin D3 [25- (OH) Vit D3], interleukin-10 (IL-10) and IgE in infants with repeated wheezing in Foshan City, Children were compared to explore the clinical significance. Methods Twenty-five cases of asthmatic infants with recurrent wheezing were selected as study group and 25 healthy children as control group. Serum 25- (OH) Vit D 3, IL-10 and Ig E levels were measured in all subjects. Observed and compared the difference between the two groups. Results The serum levels of 25- (OH) Vit D3 in the study group were (48.26 ± 14.36) nmol / L lower than those in the control group (89.77 ± 14.36) nmol / L and 24.11 ± 6.52 pg / (43.26 ± 10.21) pg / ml and (165.50 ± 23.47) IU / ml was significantly higher than that of the control group (116.13 ± 12.18) IU / ml, the difference was statistically significant (P <0.05). Conclusion There is also a lack of Vitamin D in infants with repeated wheezing at low latitudes in Foshan. Supplementing with Vit D may be one of the factors that can prevent recurrent wheezing.