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目的 探讨乌司他丁对急诊腹部手术患者应激反应的影响。方法 4 8例急诊腹部手术患者随机分为观察组和对照组 ,每组 2 4例。观察组术后每日经静脉滴注乌司他丁 2 0万U ,共 3天。对患者术前、术后应激反应的部分指标 :白细胞计数、C 反应蛋白、血糖、前白蛋白和皮质醇浓度进行测定。结果 术前各项指标无差异 ,术后血清白细胞计数、C 反应蛋白、血糖和皮质醇浓度观察组均明显低于对照组 (P <0 .0 5 ) ,前白蛋白浓度观察组明显高于对照组 (P <0 .0 5 )。结论 术后应用乌司他丁能减轻机体的应激反应 ,稳定内环境 ,有利于急诊腹部手术患者术后的康复
Objective To investigate the effect of ulinastatin on the stress response in patients undergoing emergency abdominal surgery. Methods Forty eight patients undergoing emergency abdominal surgery were randomly divided into observation group and control group, with 24 cases in each group. The observation group received intravenous drip of 200,000 U of ulinastatin daily for 3 days. The preoperative and postoperative patients with stress response to some indicators: white blood cell count, C-reactive protein, blood glucose, prealbumin and cortisol concentrations were measured. Results There was no difference in the preoperative indexes. The postoperative serum leukocyte count, C-reactive protein, blood glucose and cortisol concentration in the observation group were significantly lower than those in the control group (P <0.05), and the prealbumin concentration in the observation group was significantly higher than that in the observation group Control group (P <0.05). Conclusion Ulinastatin can reduce the body’s stress response, stabilize the internal environment and facilitate postoperative recovery of patients undergoing emergency abdominal surgery