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目的评价干扰素对ＨＢＶ前Ｃ区突变株的应答反应。方法对１０４例慢性乙型肝炎患者，应用克隆测序和快速检测ＨＢＶ前Ｃ区终止密码突变的方法，共检出２１例突变株，其中１６例曾应用干扰素治疗；野生株２１／２５例曾应用干扰素治疗。结果１６例ＨＢＶ前Ｃ区突变株对干扰素治疗有应答者６例；野生株２１例，对干扰素有应答者９例，二组相比差异无显著性。结论ＨＢＶ前Ｃ区突变株及野生株对干扰素均有部分应答，应答率分别为３７．５％和４２．９％，二组相比差异无显著性
Objective To evaluate the response of interferon to HBV pre-C mutant. Methods Totally 104 out of 104 patients with chronic hepatitis B were detected by cloning and sequencing and rapid detection of mutations in the stop codon of pre-HBV C region. A total of 21 mutants were identified, of which 16 were treated with interferon. 21/25 wild strains Interferon therapy. Results Sixteen cases of HBV pre-C mutation were found to respond to interferon therapy. There were 21 wild-type strains and 9 responders to interferon. There was no significant difference between the two groups. Conclusion The pre-HBV C mutants and wild-type strains have partial response to interferon, the response rates were 37.5% and 42.9%, respectively, with no significant difference between the two groups