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目的探讨Ghrelin基因Leu72Met多态性与T2DM之间的相关性。方法采集316例T2DM患者和203名健康对照组(NGT组)人群的一般临床资料,利用PCR-RFLP进行Ghrelin基因Leu72Met的多态性分析。结果 T2DM组的Leu72Met基因型分布及等位基因频率与NGT组相比差异无统计学意义。NGT Met72携带者血清LDL-C水平较同组Leu72纯合子个体增高(P<0.05)。结论 Ghrelin基因Leu72Met分布与等位基因频率在T2DM和健康人群无明显差异,该基因多态性在健康人群可能与血清LDL-C水平相关。
Objective To investigate the association between Ghrelin gene Leu72Met polymorphism and T2DM. Methods The clinical data of 316 patients with T2DM and 203 healthy controls (NGT) were collected. The polymorphism of Ghrelin gene Leu72Met was analyzed by PCR-RFLP. Results The Leu72Met genotype distribution and allele frequency in T2DM group were not significantly different from those in NGT group. The level of serum LDL-C in NGT Met72 carriers was higher than that in Leu72 homozygotes (P <0.05). Conclusion The distribution of Leu72 Met in Ghrelin gene is not significantly different from the allele frequency in T2DM and healthy subjects. The polymorphism of Ghrelin gene may be related to the level of serum LDL-C in healthy subjects.