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The inhibitory effect of rabbit blastocystic peptides (RBPs) on lymphocyte transfor-mation was studied by the method of measuring the incorporation of ~3H- thymidine intoDNA. The results indicated that RBPs inhibited PHA-stimulated rat and human lympho-cyte transformation in vitro. In the concentration ranging from 40 to 200 μg/2.5 ml, theinhibition was dose-dependent. No obvious inhibitory action was found with hCG (16- 128IU/2.5 ml), progesterone (250 ng- 1 μg/2.5 ml) and pregnant rabbit serum. It was furtherdemonstrated that RBPs at a higher dosage (200 μg/ml) was inhibitory to PGF_(2α) secretion.On the other hand, the ~3H- leucine incorporation of rabbit endometrium was enhanced bythese peptides, and this action could be blocked by the addition of actidine.
The inhibitory effect of rabbit blastocystic peptides (RBPs) on lymphocyte transfor-mation was studied by the method of measuring the incorporation of ~ 3H-thymidine into DNA. The results indicated that RBPs inhibited PHA-stimulated rat and human lympho-cyte transformation in vitro. No significant inhibitory action was found with hCG (16-128 IU / 2.5 ml), progesterone (250 ng- 1 μg / 2.5 ml) and pregnant rabbit It was further demonstrated that that RBPs at a higher dosage (200 μg / ml) was inhibitory to PGF_ (2α) secretion. On the other hand, the ~ 3H-leucine incorporation of rabbit endometrium was enhanced by the peptides, and this action could be blocked by the addition of actidine.