目的:研究清热益气中药黄连人参对药对自发性2型糖尿病大鼠糖代谢调节及胰岛病理形态的作用。方法:采用高热量高脂饲料喂养诱导GK大鼠,建立自发性T2DM大鼠模型,设立模型组和治疗组,治疗组予黄连人参对药干预4周,并设Wistar大鼠作为空白对照,观察体质量、血糖、空腹胰岛素、糖耐量试验,进行胰腺病理学检测。结果:黄连人参对药组负荷后2 h血糖及血糖曲线下面积均低于模型组,胰岛β细胞指数水平较模型组升高,胰岛病理损伤及纤维化程度较模型组轻。结论:清热益气中药黄连人参可降低糖尿病大鼠血糖水平,改善胰岛功能,促进胰岛细胞损伤修复。 Objective: To investigate the effect of Chinese herb “Huanglian Ginseng” on the regulation of glucose metabolism and islet pathology in spontaneously type 2 diabetic rats. Methods: GK rats were induced by high-calorie and high-fat diet to establish a spontaneous T2DM rat model. The model group and the treatment group were established. The treatment group was treated with berberine for 4 weeks. Wistar rats were used as blank control Body weight, blood glucose, fasting insulin, glucose tolerance test, pancreatic pathological examination. Results: The area under the curve of blood glucose and blood glucose of the Coptis ginseng group was lower than that of the untreated group at 2 h after loading, and the level of pancreatic β-cell index was higher than that of the model group. The degree of pancreatic islet lesion and fibrosis were lighter than that of the model group. Conclusion: Qingre Yiqi Chinese medicine, Huanglian ginseng can reduce blood glucose levels in diabetic rats, improve islet function and promote islet cell injury repair.