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目的:晚期糖基化终产物(AGEs)在许多糖尿病的并发症及衰老的发生发展中起着十分重要的作用。本研究目的是探讨晚期糖基化终产物(AGEs)对内皮细胞形态和功能的影响及其细胞信号转导机制。方法:通过采用血清白蛋白与葡萄糖共孵育制备AGEs,并复制AGEs刺激的动物模型;采用特异荧光
OBJECTIVE: Advanced glycation end products (AGEs) play a very important role in many complications of diabetes and the development of aging. The purpose of this study was to investigate the effects of advanced glycation end products (AGEs) on the morphology and function of endothelial cells and their cell signaling mechanisms. METHODS: AGEs were prepared by co-incubation of serum albumin and glucose, and AGEs stimulated animal models were reproduced. Specific fluorescence