Objective To discuss the indications for intratracheal intubation in plateau tibetans with asphyxia neonatorum, clinical therapeutic effect relationship, changes of beta2- microglobulin( β2-MC) and creatinine( Cr). Methods 48 cases of asphyxia neonatorum were divided into several groups and underwent intratracheal intubation. Radioimmunoassay was used to determined plasmaβ2- MC level in different groups which were divided according to the severity and onset time of asphyxia neonatorum.And their serum Cr level was also determined by using HTT- ACHI7060 automatic biochemical analyzer.The results were compared with those of 20 healthy mature neonates. Results The incidence of complications of the second group with asphyxia neonatorum was higher than that of the first group. The changing degrees ofβ2 - MC and Cr were parallel with the degree of asphyxia and hypoxia. Conclusion Serumβ2- MC and Cr are the sensitive indications reflecting glomerular filtration function in asphyxia neonatorum. Popularizing novel resuscitation is the key to decrease prevalence and mortality.