由内源凝血途径继发生成的大量凝血酶可以活化一个被称之为凝血酶可以活化的纤溶抑制物，活化的该物质具有下调纤溶活性的作用，从而保护血凝块不被纤溶酶过早地溶解，而使血栓更加稳定和牢固。通过干扰内源凝血途径的关键环节，不但可以使血凝块形成的体积变小，而且还可以使其对纤溶酶的溶解作用变得更加敏感。这将为血栓性疾病的治疗提供新的思路。 Thrombin, which is secondary to the endogenous coagulation pathway, activates a fibrinolytic inhibitor called thrombin that activates fibrinolysis, which has the effect of reducing fibrinolytic activity and thus protecting the blood clot from fibrinolysis Enzymes prematurely dissolve, leaving thrombus more stable and firm. By interfering with the crucial link of the endogenous coagulation pathway, not only can the volume of the clot be reduced, but it can also make it more sensitive to plasmin solubilization. This will provide new ideas for the treatment of thrombotic diseases.